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BioScreening - organic compounds for screening
News: Cancer ResearchNine U.S. Health Research Centers to Receive $255 Million - Nine health research centers have received funds to develop ways to reduce the time it takes for clinical research to become treatments for patients. The funds were awarded as part of the Clinical and Translational Science Awards (CTSA) program which is led by the National Center for Research Resources (NCRR), part of the National Institutes [...]
Using SPA to Screen Compressed Plates for Monoamine Receptor Ligands - Scintillation Proximity Assay technology (SPA) provides a homogeneous assay format that is useful for receptor ligand binding assays. The homogeneous nature eliminates the separation steps necessary for filtration assays and enables optimization for automated high-throughput drug screening. Applying this technology to 384-well plate formats has allowed researchers to further increase assay throughput. However, not every [...]
Using Nitroglycerin To Treat Prostate Cancer Shows Potential - Treatment of prostate cancer using a very low dose of nitroglycerin may slow and even halt the progression of the disease without the severe side effects of current treatments, Queen’s University researchers have discovered The findings are the result of the first-ever clinical trial using nitroglycerin to treat prostate cancer. The 24-month, Phase II study [...]
A New Approach To Cancer Drug Development - Dr. Nick recently posted a blog entry describing the need for a change to the approach used to develop to new cancer therapeutics. Echoing a point made by Dr. Stephen Neidle (Dir. of Cancer Drug Development at the University of London), he says that most of the low-hanging fruit has been harvested. During the early [...]
Scientist developing new way to diagnose, treat cancer Read more: Scientist developing new way to diagnose, treat cancer – Philadelphia Business Journal: - Ira S. Ayene is working on a new way to fight cancer. His strategy involves targeting tumor cells under metabolic stress caused by lower than normal concentrations of glucose in their environment. Glucose, a sugar, is the body’s primary source of energy. Ayene has developed a compound that would be toxic for cells in low [...]
Study Shows New Compound May Be a Therapy for Drug-Resistant Lung Cancer - Dec. 29, 2009 — Scientists at the Dana-Farber Cancer Institute say they have developed a compound that may be capable of halting a common type of drug-resistant lung cancer. Their study is published in the Dec. 24/31 issue of the journal Nature. The researchers say the framework of the new compound is different from that [...]
Does Sun Exposure Cause Skin Cancer? - There are a lot of tales told about skin health. One of the most damaging is that sun exposure causes skin cancer. As you’ll see in a moment, this is simply not true. Melanoma is the form of skin cancer the media likes to refer to when they want to scare the dickens out of [...]
Research yields new agent for some drug-resistant non-small cell lung cancers - BOSTON–The ability to make, test, and map the atomic structure of new anti-cancer agents has enabled a team of Dana-Farber Cancer Institute scientists to discover a compound capable of halting a common type of drug-resistant lung cancer. In a study to be published in the December 24/31 issue of the journal Nature, the researchers report [...]
Bioluminescence imaging allows real-time monitoring of cancer spreading through the body - (Nanowerk News) Scientists from A*STAR in Singapore and the USA have developed a fast bioluminescence imaging technique that may greatly assist in the search for drugs that target mobile—or metastatic—cancer cells (“A screening platform for glioma growth and invasion using bioluminescence imaging Laboratory investigation”). Chemotherapy treatments for this type of cancer using ‘anti-migratory’ drugs are [...]
New Agent for Some Drug-Resistant Non-Small Cell Lung Cancers - ScienceDaily (Dec. 28, 2009) — The ability to make, test, and map the atomic structure of new anti-cancer agents has enabled a team of Dana-Farber Cancer Institute scientists to discover a compound capable of halting a common type of drug-resistant lung cancer. In a study to be published in the December 24/31 issue of the [...]
We’re winning the war on cancer - What does yesterday’s exciting news of the complete DNA sequencing of two different cancers mean? It is a fantastic feat that promises great improvements in our ability to cure cancer by 2020, but it comes with a hefty price tag. The numbers are stark. One in three of us will get cancer, and 1.5 million [...]
Colon Cancer – Does Wheat Bran Reduce the Risk? - K-State, Wichita State collaborative research studies wheat bran from different wheat varieties, effect on suppressing colon cancer MANHATTAN — We’ve heard the conflicting information: Wheat bran can reduce the risk of colon cancer in humans; wheat bran does not reduce the risk in humans. But which one is true? Both, sort of. In the mid-1990s, [...]
Anti-cancer compound wins scientist Biota Award - Walter and Eliza Hall Institute scientist Dr Guillaume Lessene has won this year’s Biota Award for Medicinal Chemistry, awarded by the Royal Australian Chemical Institute. Dr Lessene, who runs a laboratory in the institute’s Structural Biology Division, won the award for his role in the discovery of several compounds that interact with a protein that [...]
AACR-NCI-EORTC conference highlights major expansion in cancer drug pipeline - The last decade has seen a major expansion in the cancer drug pipeline and studies are continually underway to advance the arsenal of drugs and create more effective treatments and targeted therapies for patients. To highlight results of more recent research, the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International Conference will host a press briefing [...]
Tapeworm Drug May Hold Promise For Colon Cancer, Future Research - The findings about this compound, published in the Nov. 3 issue of Biochemistry journal, might prove valuable to patients and clinicians, who may benefit if there is a demonstrated boost to chemotherapy. Researchers also can use the compound to manipulate the receptor to learn more about a common cell replenishing pathway, called the Wnt pathway, [...]
Glycotope receives regulatory approval for GlycoExpressTM Technology and initiates first clinical trial with lead antibody GT-MAB 2.5-GEX TM - Berlin, Germany, November 25, 2009 / b3c newswire / - Glycotope GmbH, a leading German Biotech company, has received regulatory approval by Germany and Italian regulatory authorities for a Phase I study of Glycotope´s lead antibody GT-MAB 2.5-GEXTM for the treatment of various solid cancers. The approvals further underline the suitability of Glycotope´s proprietary GlycoExpressTM [...]
Scientists hope mouse research leads to new anti-cancer therapies - Can an experiment with rodents lead to the end of breast cancer as we know it? Recent collaborative work between Cambridge, Mass., research institutes has discovered a method of screening for chemicals that selectively kill breast cancer stem cells in culture and in mice, a breakthrough that may directly or indirectly lead to new anti-cancer [...]
PharmaGap Reports That GAP-107B8 Showed Strong and Consistent Anti-Cancer Activity in a Wide Range of Cancers in NCI Test - OTTAWA, ONTARIO, Oct 27, 2009 (MARKETWIRE via COMTEX) —-PharmaGap Inc. (TSX VENTURE: GAP)(OTCBB: PHRGF) (“PharmaGap” or “the Company”) is pleased to announce highly positive results from the United States National Cancer Institute (“NCI”) 5-dose in vitro anti-cancer screen of PharmaGap drug GAP-107B8. These results confirm and extend results announced in August from the single-dose study [...]
PharmaGap Advises That NCI Test Results Are Completed and Expected to Be Provided to the Company Shortly - OTTAWA, ONTARIO — 10/20/09 — PharmaGap Inc. (TSX VENTURE: GAP)(OTCBB: PHRGF) (“PharmaGap” or “the Company”) advises that the results of dose-range testing of the Company’s cancer drug GAP-107B8 at the United States National Cancer Institute (“NCI”) can be expected “shortly”. NCI staff has indicated to the Company that testing has been completed and the results [...]
Novel two-step chemical process makes cancer cells glow quickly, safely - WASHINGTON – Researchers at Massachusetts General Hospital have developed a two-step process that uses a chemical reaction to make live cancer cells light up quickly and safely. This attains significance because scientists generally label cells with coloured or glowing chemicals to observe how basic cellular activities differ between healthy and cancerous cells, but existing techniques [...]
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