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BioScreening - organic compounds for screening
News: Discoveries, Innovations and PatentsExperimental drug shows some benefit for Huntington’s disease - An experimental drug call latrepirdine has produced a small improvement in the mental abilities of some patients with Huntington’s disease, a finding that sets the stage for a larger clinical trial. Although the improvement was modest, the study marks the first time that a drug has been shown to improve brain function in the disorder. [...]
Eli Lilly and GlaxoSmithKline: A Tale of Two Different Pharmas - New models for drug development, especially in big pharma, are being experimented by different companies. Eli Lilly (LLY) and GlaxoSmithKline (GSK) have two different models. These models do not throw out the old ones – but do offer additional routes going forward. Lilly has a Phenotypic Drug Discover Initiative, (or PD2), launched in 2009. Lilly [...]
Sleep with the Fishes Zebrafish larvae are a surprisingly compatible stand-in for humans as researchers test the next generation of insomnia drugs. - There’s a new guinea pig in the search for sleep-related drugs: the zebrafish. Researchers at Harvard University have developed a screening tool that tests the effects of thousands of compounds on zebrafish behavior in an effort to discover new pathways that govern sleep. The research, published this week in the journal Science, may result in [...]
Hi-tech microscopes make androgen therapy ‘personal’ - HOUSTON — (December 9, 2009) — On rare occasions, an infant is born with outward appearance of a female but the XY chromosomes of a male. If the child has a normal Y chromosome — the chromosome responsible for testicular development — the condition is known as androgen insensitivity syndrome. Experts estimate such births occur [...]
Forma Therapeutics raises $25.5M in Series B round - Forma Therapeutics has closed on a Series B financing that raised a total of $25.5 million. The round was led by new investor Lilly Ventures. Lilly was joined by existing investors Novartis Option Fund and Bio*One Capital of Singapore. Lexington-based Cubist Pharmaceutical, Inc. also joined as a new equity investor through a conversion of a [...]
JAX–West Helps Search for Compounds That Radically Extend Lifespan - In 2004, Avi Kremer, a 29-year old Harvard Business School student, was diagnosed with ALS. Avi’s doctors told him there was nothing that modern medicine could do for him. In response, he and fellow students founded Prize4Life, Inc. , a non-profit organization dedicated to accelerating research for treating and curing ALS by using the leverage [...]
DG-AMMOS: A New tool to generate 3D conformation of small molecules using Distance Geometry and Automated Molecular Mechanics Optimization for in silico Screening. - Discovery of new bioactive molecules that could enter drug discovery programs or that could serve as chemical probes is a very complex and costly endeavor. Structure-based and ligand-based in silico screening approaches are nowadays extensively used to complement experimental screening approaches in order to increase the effectiveness of the process and facilitating the screening of [...]
UT professor receives grant for new process - Using a pair of tweezers, a UT graduate student carefully lifted a nylon mesh square about the size of a thumbnail out of a small flask in his team’s lab. The nylon had been soaking in a clear, watery solution containing a chemical compound — the “capture agent†— that it would bind with during [...]
Tapeworm Drug May Hold Promise For Colon Cancer, Future Research - The findings about this compound, published in the Nov. 3 issue of Biochemistry journal, might prove valuable to patients and clinicians, who may benefit if there is a demonstrated boost to chemotherapy. Researchers also can use the compound to manipulate the receptor to learn more about a common cell replenishing pathway, called the Wnt pathway, [...]
Scientists hope mouse research leads to new anti-cancer therapies - Can an experiment with rodents lead to the end of breast cancer as we know it? Recent collaborative work between Cambridge, Mass., research institutes has discovered a method of screening for chemicals that selectively kill breast cancer stem cells in culture and in mice, a breakthrough that may directly or indirectly lead to new anti-cancer [...]
PharmaGap Reports That GAP-107B8 Showed Strong and Consistent Anti-Cancer Activity in a Wide Range of Cancers in NCI Test - OTTAWA, ONTARIO, Oct 27, 2009 (MARKETWIRE via COMTEX) —-PharmaGap Inc. (TSX VENTURE: GAP)(OTCBB: PHRGF) (“PharmaGap” or “the Company”) is pleased to announce highly positive results from the United States National Cancer Institute (“NCI”) 5-dose in vitro anti-cancer screen of PharmaGap drug GAP-107B8. These results confirm and extend results announced in August from the single-dose study [...]
Aeolus Drug Protects the Gastrointestinal Tract in Acute Radiation Syndrome Studies Sponsored by the National Institutes of Health`s National Institute for Allergy and Infectious Diseases - * AEOL 10150 Effectively Increases Regeneration of GI Stem Cells and Reduces the Severity and Duration of Diarrhea * Drug Improves Survival When Administered 24 Hours after Total Body Irradiation MISSION VIEJO, Calif.--(Business Wire)-- Aeolus Pharmaceuticals, Inc. (OTCBB: AOLS) announced today that recent experiments in preclinical models conducted by the National Institutes of Health`s (NIH), [...]
Researchers find candidates for new HIV drugs - While studying an HIV protein that plays an essential role in AIDS progression, researchers at the University of Pittsburgh School of Medicine have discovered compounds that show promise as novel treatments for the disease. HIV drug discovery efforts have met with little success in finding compounds that interact with an important HIV virulence factor, called [...]
Scientists get closer to making safe patient-specific stem cells - Scientists are a big step closer to their long-term of goal of creating patient-specific stem cells that are safe to use and don’t require the destruction of embryos. Induced pluripotent stem cells – also known as iPS cells – are all the rage in the nascent field of regenerative medicine. Like embryonic stem cells, they [...]
Scripps Research scientists awarded $3.9 million grant to develop new compound screening platform - Bicoastal effort could help revolutionize the search for new therapies La Jolla, CA, and Jupiter, FL, October 5, 2009 –A pair of scientists from The Scripps Research Institute, one on each coast, has been awarded a five-year $3.9 million grant from the National Institutes of Health (NIH) to develop a new technology to accelerate the [...]
AIDS Study Flushes Out Hidden Virus, Pointing to Possible Cure - Oct. 2 (Bloomberg) — Scientists, moving closer to a cure for AIDS, identified a way to find medicines that would help rid patients of the hardest-to-treat pockets of HIV. Current anti-HIV drugs reduce the virus to undetectable levels without eradicating it. The virus survives by lying dormant in immune-system cells, where the medicines don’t reach [...]
GENFIT identifies compounds which modulate clock genes for the treatment of cardiometabolic disease and CNS disorders - Lille (France), Cambridge (Massachusetts, United States), September 28, 2009 – GENFIT (Alternext: ALGFT; ISIN: FR0004163111), a biopharmaceutical company at the forefront of drug discovery and development, focusing on the early diagnosis and preventive treatment of cardiometabolic and neurodegenerative diseases, today announces the successful identification of Hit compounds for an orphan nuclear receptor which plays a [...]
Novel two-step chemical process makes cancer cells glow quickly, safely - WASHINGTON – Researchers at Massachusetts General Hospital have developed a two-step process that uses a chemical reaction to make live cancer cells light up quickly and safely. This attains significance because scientists generally label cells with coloured or glowing chemicals to observe how basic cellular activities differ between healthy and cancerous cells, but existing techniques [...]
Sirona Biochem Says SGLT Test Results Confirm Key ‘Breakthrough’ - Sirona Biochem Corp. (TSX-V: SBM), an emerging biotech company focused on diabetes and obesity, says results of testing its unique SGLT inhibitor molecules demonstrate a key breakthrough milestone for Sirona Biochem. Sirona Biochem CEO, Dr. Howard Verrico, said, “There are two vital steps in the early stage of drug testing: validation of concept i.e. a [...]
Agilux Laboratories Hires New Associate Director to Lead In Vitro ADMET Services Division - - Adrian Sheldon, Ph.D., Positions Contract Research Organization for Growth - WORCESTER, Mass.--(Business Wire)-- Agilux Laboratories, Inc., a Contract Research Organization (CRO) that provides bioanalytical and in vitro Absorption Distribution Metabolism Excretion Toxicology (ADMET) services for the biotechnology and pharmaceutical industries, has appointed Dr. Adrian Sheldon as associate director of In Vitro ADMET Services. In [...]
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