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BioScreening - organic compounds for screening
News: Discoveries, Innovations and PatentsInvitrogen Scientists Link microRNA Sequences to Cancer Using RNA Samples from BioServe - Carlsbad, Calif., and Beltsville, Md., May 7, 2008 – In research demonstrating that RNA previously thought to have no biological relevance may be of use for therapeutic and diagnostic targets, Invitrogen Corporation (NASDAQ:IVGN), a provider of essential life science technologies for research, production and diagnostics, and BioServe, the leading provider of clinically annotated tissue samples [...]
When extractions go toxic - By extracting information from a freely-available chemical database, Italian forensic scientists have come up with a simple but highly effective method for identifying unknown toxicological compounds in biological samples.
A central component of forensic analysis and drug testing, toxicological analyses of biological samples have traditionally been conducted using gas chromatography/mass spectrometry (GC/MS), with compounds identified by [...]
Ono Enters into a New Fragment-Based Drug Discovery Agreement with Evotec - Hamburg, Germany | Oxford, UK - Evotec AG (Frankfurt Stock Exchange: EVT) announced today that the Company and Ono Pharmaceutical Co., Ltd. (Osaka, Japan) signed a new drug discovery agreement targeting a protease chosen by Ono.
The collaboration applies Evotec’s proprietary fragment-based drug discovery platform, EVOlutionTM to identify novel, small molecular weight compounds active against a [...]
Health Care’s Silent Spring - As the Intergovernmental Working Group (IGWG) of the WHO prepares to meet and discuss how to best facilitate the expropriation of intellectual property rights (in this case the IPR of pharmaceutical patents) it’s important to consider the unintended consequences — the death of medical innovation.
The global purloiners of patents — led by Jamie Love — [...]
BIO Spent $6.6 Million on Lobbying Efforts in 2007 - The Biotech Industry Organization (”BIO”) spent $6.6 Million on lobbying efforts in 2007, reported the Associated Press.
BIO’s lobbying efforts last year addressed a range of issues from patent reform to generics to FDA-related issues. The Associated Press reported as follows:
[BIO’s] lobbying efforts went toward cloning issues ahead of the Food and Drug Administration’s ruling [...]
SRI helps develop screening program for AIDS drugs - Research conducted at Birmingham’s Southern Research Institute helped develop a system to identify drugs with the ability to fight the virus that causes AIDS.
Trana Discovery, a North Carolina-based drug discovery technology company, worked with Southern Research to create a screening system to identify drugs that inhibit HIV replication.
The system can be used by pharmaceutical companies [...]
Research could open door for rare neurological disorder - An unexpected finding turned out to be a clue leading researchers at Washington University School of Medicine in St. Louis to propose a new treatment approach for Niemann-Pick disease, a rare, deadly neurodegenerative disorder. To overcome the genetic defect in Niemann-Pick disease, the researchers suggest that chemical compounds could potentially “chaperone” mutant protein molecules through [...]
Biological Drugs Spurring an Evolution in Injectable Drug Delivery - (Amherst, NH) - The success of recombinant protein drugs such as Enbrel, Remicade, and Herceptin in treating refractory conditions is fueling the search for protein and peptide-based therapeutic agents in oncology, inflammation and a host of other disease classes. Led by the proliferation of antibody-based drug candidates, biological drugs as a class continue to outpace [...]
New drug target leaves lung cancer cells alone, lonely and dying - It seems even tumour cells can get lonely; scientists have discovered that by cutting off a key gene, lung cancer tumour cells are left ‘homeless’ and they can’t survive on their own.
The gene in question is called 14-3-3zeta and it can now be considered a potential target for selective anticancer drugs, according to Professor Haian [...]
Theravance Announces Initiation of Phase 1 Clinical Study with Investigational Medicine for Respiratory Disease - Theravance, Inc. (NASDAQ: THRX) today announced that GlaxoSmithKline plc (GSK) initiated subject screening in a Phase 1 clinical study designed to assess the safety, tolerability, and pharmacokinetics of an investigational, inhaled bronchodilator, GSK1160724, for the treatment of chronic obstructive pulmonary disease (COPD). The compound was discovered by Theravance and is being developed by GSK [...]
Genoway launches standardized genetically modified mousse and rat - The biotechnology company continues its strong growth (+50% tendency) and
reinforces its international leadership in the development and supply of genetically
modified animal models. The products henceforth available from the catalogue
have already attracted Pfizer, GSK, BMS and Servier.
Lyon (France), 19 November 2007 - genOway, a biotechnology company specialized in
the development of genetically modified research models for the [...]
Antidepressant Found To Extend Lifespan In C. Elegans - ScienceDaily (Nov. 22, 2007) — A team of scientists led by Howard Hughes Medical Institute (HHMI) investigator Linda B. Buck has found that a drug used to treat depression can extend the lifespan of adult roundworms.
Buck and colleagues Michael Petrascheck and Xiaolan Ye report in the November 22, 2007, issue of the journal Nature, that [...]
Device Offers Pharmaceutical Makers A Fast, Cheap and Safe Way to Screen Potential Drug Compounds - A new device invented by researchers at the University of Virginia could save pharmaceutical companies significant time and money in screening potential new drug compounds.
“We want to help the pharmaceutical industry identify effective therapuetic compounds by allowing them to fail early, fail fast, and fail cheap before going to very expensive animal studies,” said Brett [...]
New Database Screening Criteria Improves Identification Of Anticancer Drugs - Scientists in Indiana and Michigan have developed a better way of mining a vast computerized database for chemical nuggets that could become tomorrow’s cancer medications.
The new “data mining” method pinpoints chemical structures with drug-like activity. It could speed the identification and development of new, more effective drugs against breast, prostate, lung and other cancers.
Computers have [...]
Magellan BioScience Group, Inc. and the University of Medicine and Dentistry of New Jersey enter into anti-Leukemia Drug Discovery Collaboration - Tampa, FL – Magellan BioScience Group, Inc. (Magellan), a pioneer in innovative drug discovery and development from marine microbial sources, and the University of Medicine and Dentistry of New Jersey (UMDNJ) announced today that they have entered into an anti-leukemia drug discovery collaboration. Magellan will team with UMDNJ scientist Dr. Scott Kachlany.
This collaboration will bring [...]
Bio-IT Briefs - November 01, 2007 | Ambit Biosciences announced a second expansion of its collaboration with Bristol-Myers Squibb (BMS) for the discovery and development of novel kinase inhibitors. As part of this expansion, Ambit will screen BMS’s kinase-focused library using Ambit’s proprietary KinomeScan technology. KinomeScan is a high-throughput method for screening small molecule libraries against a large [...]
FDA approves Merck’s Isentress for HIV - Oct 16, 2007 (Datamonitor via COMTEX) — MRK | charts | news | PowerRating — The FDA has granted Merck & Co.’s Isentress tablets accelerated approval for use in combination with other antiretroviral agents for the treatment of HIV-1 infection in treatment-experienced adult patients who have evidence of viral replication and HIV-1 strains resistant to [...]
Sigma-Aldrich Introduces N-TER Nanoparticle siRNA Transfection System for Delivery of siRNA Into Difficult-to-Transfect Cell Types - ST. LOUIS, Oct. 18 /PRNewswire-FirstCall/ — Sigma-Aldrich announced today the global release of the N-TER(TM) Nanoparticle siRNA Transfection System. N-TER allows researchers to reproducibly interrogate gene function, via siRNA transfection, in model cell types that have previously not been considered amenable to conventional lipid-based siRNA delivery reagents.
“Traditional lipid-based siRNA transfection reagents exhibit a number of [...]
Novartis weighs up label-free HTS for drug discovery - Researchers from Novartis have published results using high-throughput screening (HTS) mass spectrometry (MS) techniques for the identification of enzyme inhibitors.
HTS techniques have become an important part of the drug discovery process allowing researchers to sift through massive libraries of compounds to find ‘hits’ that are active against a therapeutic target of interest.
This latest research, published [...]
New Compounds With Anti-Inflammatory Properties Discovered Through Expansive PhytoLogix(TM) Botanical Library - Lacey, WA – Researchers utilizing one of the world’s largest ethnomedicinal plant libraries recently developed two highly potent flavonoid formulas which convey topical anti-inflammatory effects. The botanicals, a catechin derived from the catechu tree and baicalin extracted from Chinese skullcap, were combined in two different formula ratios and then evaluated for anti-inflammatory and antioxidant effects. [...]
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