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BioScreening - organic compounds for screening
News: Natural Products, Natural CompoundsMumie - Description and Origin - Though Mumie has been used in folk medicine of different countries for almost two thousand years, there are still many legends regarding its mysterious origin. In Russia serious research has been conducted on Mumie since 1910. This research became even more intense during the past twenty years Government financing supported research that was conducted at [...]
Gossypol Biological Properties - Gossypol:
is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
is antimalarial being the selective inhibitor of Plasmodium falciparum (pfLDH over hLDHs), an essential enzyme for energy generation within malarial parasite.
posesses proapoptotic properties, probably due to the regulation of the Bax and Bcl2.
reversibly inhibits Calcineurin and binds to calmodulin.
inhibits replication [...]
MerLion Pharmaceuticals Pte Ltd Announces The Completion Of Merger With Combinature Biopharm AG And Athelas SA; Closure Of US $30 Million Financing Round - MerLion Pharmaceuticals Pte Ltd (MerLion) of Singapore, the world’s leading natural products based drug discovery company, announces that it has completed a merger by exchange of shares with Combinature Biopharm AG (Berlin, Germany) and Athelas SA (Geneva, Switzerland).
SINGAPORE, Singapore | Aug 21, 2006 | MerLion Pharmaceuticals Pte Ltd (MerLion) of Singapore, the world’s leading natural [...]
Elsevier MDL and Key Organics partner to improve chemical sourcing - San Ramon, CA, May 8, 2006 - Elsevier MDL, producer of the MDL® Available Chemicals Directory and MDL® Screening Compounds Directory databases, and Key Organics Ltd., a leading supplier of screening compounds and chemical building blocks, have partnered in an effort to provide improved access to timely, accurate information for chemical sourcing and procurement for [...]
Plant Compounds Inhibit Blood Clotting - After screening hundreds of phytochemicals found in a variety of plants, an ARS scientist has identified, characterized, and synthesized two potentially heart-healthy natural compounds.
These compounds, either in foods or as dietary supplements, may be important for alleviating the symptoms of heart disease related to blood clots. Rigorous testing and regulatory approval is prerequisite.
The research [...]
Gossypol. What is it? - What is it?
Gossypol is an herbal medicine used to treat cancer and a female problem called endometriosis. It may also be used by women and men to prevent pregnancy.
Other names for Gossypol include: Gossypium hirsutum and Cottonseed oil.
Ask your doctor, nurse, or pharmacist if you need more information about this medicine or if any information [...]
New Attractiveness of Plant-Derived Natural Products - BioPlanta GmbH and AnalytiCon Discovery GmbH announce their cooperation in the plant-based search for active ingredients.
Leipzig, 09/06/2005 - The aim of the cooperation between BioPlanta and AnalytiCon is to find and to develop new plant-derived active ingredients for use in medicinal therapy. The potential for continuous production of these plant-derived pure compounds - independent of [...]
In Search Of Bioactive Shapes - Metal complexes that mimic the shapes of natural products show unique properties
Natural products are classic inspirations for, and indeed sources of, therapeutic agents, but they are scarce and often painstaking to make by synthetic means. At the American Chemical Society national meeting this week in Washington, D.C., Eric Meggers of the University of Pennsylvania demonstrated [...]
SA, India, Brazil in resource deal - Cape Biotech is investigating a possible bio-prospecting partnership which would enable South Africa, Brazil and India to share each other’s resources in order to capitalize on their rich biodiversity.
Bio-prospecting is the search for valuable compounds in nature - plants, animals or micro-organisms - that can assist in the development of new drugs or industrial products.
Dr [...]
AnalytiCon Discovery To Identify New Natural Compounds For Johnson & Johnson Pharmaceutical Research & Development - AnalytiCon to provide a highly purified, fully elucidated natural product compound library
Potsdam, Germany (July 12, 2005) - AnalytiCon Discovery GmbH (AnalytiCon), a specialist in all aspects of natural product drug discovery, announced it has signed an agreement that will provide Johnson & Johnson Pharmaceutical Research & Development, Division of Janssen Pharmaceutica N.V. (J&JPRD), with [...]
AnalytiCon Discovery To Identify New Natural Compounds For Johnson & Johnson Pharmaceutical Research & Development - AnalytiCon to provide a highly purified, fully elucidated natural product compound library
Potsdam, Germany (July 12, 2005) - AnalytiCon Discovery GmbH (AnalytiCon), a specialist in all aspects of natural product drug discovery, announced it has signed an agreement that will provide Johnson & Johnson Pharmaceutical Research & Development, Division of Janssen Pharmaceutica N.V. (J&JPRD), with [...]
Traditional medicines make delicate advance - An indigenous Chinese herb similar to the popular garden sage in the West has been used to treat a variety of diseases since time immemorial.
It is called danshen, or Salvia miltiorrhiza in Latin.
Despite its popularity, Xuan Lijiang, a scientist at Shanghai Institute of Materia Medica (SIMM) under the Chinese Academy of Sciences, did not expect [...]
Cottonseed Drug Boosts Cancer Treatment in Mice - Gossypol, a drug refined from cottonseed oil, and previously tried and abandoned as a male contraceptive, could boost the effectiveness of treatment for prostate cancer and possibly other common cancers as well.
New York /PSA Rising/ October 5, 2004 — Gossypol, a drug made from a toxic yellow pigment in cottonseed, for about a decade has [...]
The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. - Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA.
BACKGROUND: Racemic gossypol [(+/-)-GP], a naturally occurring polyphenolic yellow pigment present in cottonseed products, inhibits in vitro proliferation of Dunning prostate cancer cells (MAT-LyLu), human prostate cancer cells derived from a bone marrow metastasis (PC3), [...]
Producer-funded: Research would boost cottonseed use - “We’re 80 percent of the way there, but that’s not enough. Our research is continuing in Texas, Oklahoma, and California.”
Cottonseed may one day offer increased returns as a result of research efforts by Cotton Incorporated, says Bill Lalor, vice president of research for the producer-funded research/promotion organization.
“Most growers and ginners don’t see the very extensive [...]
Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. - Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, Ohio State University, Columbus 43210-1092, USA.
Gossypol (GP), an antifertility agent in males, is also capable of inhibiting the proliferation of a wide range of cancer cells in vivo and in vitro. Thus, in this study we investigated the effect of GP on the growth of [...]
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