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BioScreening - organic compounds for screening
HT Screening NewsThe NIH Molecular Libraries Program: Identifying Chemical Probes for New Medicines - Alice McCarthy In 2003, several program leaders within the National Institutes of Health (NIH) recognized that the results from the recently completed Human Genome Project were a launching pad for further study. Now that scientists knew the genome, how could they determine gene function? In particular, how could scientists find specific biological pathways and targets that [...]
Speeding up drug screening - Box 1: Speeding up drug screening Whole-cell assays allow new drugs to be screened for efficacy without knowing the molecular targets. High-throughput screens (HTSs) are vital in the quest for new compounds, but until recently have been lacking for Chagas disease. At the Swiss Tropical and Public Health Institute, Reto Brun provides a ‘gold standard’ [...]
NIH High-Throughput Screening Identifies Candidate Medicines for CMT - The NIH has completed the high-throughput screening program. Working with a chemical library of more than 350,000 compounds, the NIH screened each compound at approximately 7 different dosage levels-resulting in more than 2 million unique screens. Out of the 4000 FDA approved drugs, 10 “hits” or candidate medicines were found. At this point in time, [...]
Increased R&D Efforts Are Overcoming Obstacles and Showing Potential - Ion channels make good drug targets—they reside on the cell surface and are fast switching mechanisms. They act like cell transistors, controlling many cell processes. There are close to 500 types of ion channels, yet many remain undiscovered. This was mainly attributed to technology restraints, however, with the recent introduction of HT patch clamping, as [...]
Sanford-Burnham robots speed up path to discovery - The work force at Lake Nona’s Sanford- Burnham Institute includes 90 scientific staffers, 60 administrators and support personnel — and a team of three robots. The robots are part of a $15 million investment from the National Institutes of Health and occupy a large, glass-enclosed room on the bottom floor of Burnham’s Lake Nona campus. [...]
Compound screening for drug development made simpler - The identification of compounds that could be promising candidates for drug development has become easier following research by the Walter and Eliza Hall Institute’s medicinal chemistry group. Dr Jonathan Baell and Dr Georgina Holloway have developed a series of ‘filters’ that can be used to weed out those molecules likely to come up as false [...]
High Throughput Screening 2010 Study Finds HTS Laboratories Using Effective Screening Strategies and Innovative Technologies to Increase Drug Discovery Success - HTS laboratories are essential contributors to drug discovery, participating extensively in assay development and lead optimization as well as in primary and secondary screening of compound libraries. Effective screening strategies adopted by HTS laboratories include the use of more complex biological systems: more membrane-bound targets, more cell-based high content assays, and increased use of stem [...]
Evotec Signs High Throughput Screening Agreement With Active Biotech - Evotec AG (Frankfurt:EVT) (TecDAX) today announced that it has entered into a collaboration with Active Biotech AB (Stockholm:ACTI) to identify small molecule modulators of a priority biological target, selected by Active Biotech, involved in immune disorders and cancer. Evotec will use its expertise and technologies in assay development, high throughput screening (HTS) and surface plasmon [...]
Genentech and UCSF’s Small Molecule Discovery Center Ink Deal Targeting Neurodegenerative Diseases - The University of California, San Francisco and Genentech are partnering to discover and develop drug candidates for neurodegenerative diseases. The company will support the work of several researchers at the UCSF Small Molecule Discovery Center (SMDC) to progress prior SMDC research and Genentech discoveries. In addition to receiving financial support for its research function, UCSF [...]
An Emerald in the Rough - Late last year, scientists at Emerald BioStructures, located on Bainbridge Island just across the Puget Sound from downtown Seattle, experienced the bittersweet ride that so often characterizes the drug discovery business. In August 2009, a team led by CEO Lance Stewart published a major paper outlining the application of a Fragments of Life (FOL) drug [...]
BellBrook Labs Launches a New Transcreener HTS Enzyme Assay - Madison, Wis. (PRWEB) January 11, 2010 — BellBrook Labs today announced that it has launched a new product in their proprietary Transcreener HTS Assay platform. The Transcreener GDP FI Assay was developed for detection of GTPases, a large family of enzymes that play diverse roles in normal and disease-related cell processes. The new assay overcomes [...]
Genedata at HCA Announces Banner Year for Genedata Screener at Leading Pharmaceutical Companies - 7 out of the 25 top pharmas now use Genedata Screener for High Content Screening analysis. San Francisco, CA (PRWEB) January 11, 2010 — Genedata, a leading provider of advanced software solutions for drug discovery and life science research, today announced that over the past 12 months Genedata Screener has experienced unprecedented industry adoption with [...]
Product Focus: Ultra-High-Throughput Screening - Ultra-high-throughput screening (uHTS) is an automation-based methodology for conducting hundreds of thousands of biological or chemical screening tests per day. The cutoff between high-throughput screening (HTS) and ultra-high-throughput is somewhat arbitrary. “There is no fixed boundary,†says Simon Sheard, Ph.D., business development manager at RTS Life Science (Manchester, UK), which supplies automated sample management equipment [...]
Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis — state of the art - Fibrosis represents a major global disease burden, yet a potent antifibrotic compound is still not in sight. Part of the explanation for this situation is the difficulties that both academic laboratories and research and development departments in the pharmaceutical industry have been facing in re-enacting the fibrotic process in vitro for screening procedures prior to [...]
Enzyme binds both sides of the mirror - European chemists have discovered that both mirror-image forms of a particular compound can bind at the same time in the same site of an enzyme, a phenomenon that has never been seen before. The finding has significance for drug discovery screening and studies of how small molecules interact with proteins. Rolf Breinbauer from Graz University [...]
High-Content Screening Surges Ahead - High-content screening (HCS) and the technology to do it faster, on more compounds in a shorter period of time, and to generate quantitative, multiparametric data took center stage at CHI’s “High Content East†meeting held in Boston last month. Presenters described how they are implementing enhanced screening systems, image-analysis methods, and data-management strategies to achieve [...]
Researchers find candidates for new HIV drugs - While studying an HIV protein that plays an essential role in AIDS progression, researchers at the University of Pittsburgh School of Medicine have discovered compounds that show promise as novel treatments for the disease. HIV drug discovery efforts have met with little success in finding compounds that interact with an important HIV virulence factor, called [...]
MALDI-Based Method May Reduce Cost of Rx-Screening Assays, Speed Drug Development - This story originally ran on Oct. 6. By Tony Fong Researchers from the University of Cincinnati and MDS Analytical Technologies have used mass spectrometry to develop a high-throughput screening method for drug discovery they say can be more precise and cost-effective than existing techniques. The technique is based on a MALDI triple-quadrupole platform and exploits [...]
Structure-based substrate screening for an enzyme - Nowadays, more and more novel enzymes can be easily found in the whole enzyme pool with the rapid development of genetic operation. However, experimental work for substrate screening of a new enzyme is laborious, time consuming and costly. On the other hand, many computational methods have been widely used in lead screening of drug design. [...]
GTCbio Announces 4th Annual Assay Development and Screening Conference taking place June 8-9, 2009. - San Francisco, CA – GTCbio Announces its 4th Annual Assay Development and Screening Conference taking place June 8-9, 2009. As compounds derived from high throughput screening increasingly find their way into clinical trials, drug screening has become widely accepted as a critical step in the drug discovery process. After more than a decade of rapid [...]
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