A new hardware/software interface connects light and scanning electron microscopes for correlative microscopy in the life sciences. The Shuttle & Find interface enables users to recall regions of interest in fixed specimens in an electron microscope that were previously identified in a light microscope and vice versa. The interface allows overlay of light and electron microscope images, high-resolution magnification of the details, and the merger of functional and structural information. The key elements of Shuttle & Find for correlative light and electron microscopy are a transferable specimen holder and a software module that controls all functions of light and electron microscopes needed to identify and recall the defined region of interest.

Company: Carl Zeiss, Inc.

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