BioScreening - organic compounds for screening

30.08.2004 August 2004 News Archive
NicOx S.A. has signed a research, option, development and licensing agreement with Pfizer Inc. related to selected proprietary NicOx nitric oxide-donating compounds. Under the agreement, NicOx grants Pfizer an option to acquire an exclusive worldwide license covering early-stage nitric oxide-donating compounds in an undisclosed field. NicOX-PR 8/26/04

ChemDiv, Inc. (Chemical Diversity) and Yale University have announced that they were awarded a joint Phase I NIH grant to discover small molecule inhibitors of a G-protein coupled receptor, the melanocortin-2 receptor (MC2R). Chemical Diversity will be responsible for chemistry and high throughput screening using assays developed by the Yale scientists, who will also be responsible for performing the follow-up in depth studies into the mode of the action of the discovered hits to lead the design and synthesis of combinatorial libraries around the hits for the hit-to-lead and lead optimization programs. ChemD-PR 8/25/04

Dr. Chris Lipinski Honored by American Chemical Society for Rule of Five
Dr. Christopher Lipinski, member of the TB Alliance Scientific Advisory Committee and a retired Senior Research Fellow at Pfizer Global R&D Groton New London labs, has been honored for his groundbreaking "Rule of Five" by the American Chemical Society. On August 23rd, the ACS announced that Dr. Lipinski is the recipient of the 2005 E.B. Hershberg Award for Important Discoveries in Medicinally Active Substances. www.tballiance.org 8/23/2004

LION bioscience today announced that it has established two new partnerships with companies in the field of cheminformatics, BioByte and ChemNavigator reflecting LION’s continuing involvement in the cheminformatics field. BioByte, a pioneer in the field of QSAR will provide its cLogP™ calculation software for incorporation into LION’s LeadNavigator™ software product. BioByte’s cLogP™ software provides accurate hydrophobic estimations and calculations based on established chemical interactions, not solely on statistics, thereby providing valuable and precise information to the user. ChemNavigator a cheminformatics company dedicated to lowering the cost and risk of drug discovery, is providing LION with custom software modules which are integrated into LeadNavigator™. PR-Lion 8/24/04

Sigma-Aldrich Corporation and Caliper Life Sciences are collaborating to develop and co-market a series of automated turnkey solutions for a wide variety of applications in genomics, proteomics, and drug discovery. The two companies are developing a series of pre-optimized and validated automation protocols using Caliper's Sciclone ALH 3000 Liquid Handling Workstation with a variety of Sigma-Aldrich's biochemicals and reagent kits. PR-SIAL 8/16/04

Xantos Biomedicine has acquired access to OriGene Technologies TrueClone™ Collection of non-redundant full-length human cDNA clones. Xantos uses its High-Throughput Cellular Screening Technology, XantoScreen™ and the full-length human clone collection to identify and functionally validate novel targets. Xantos has acquired the OriGene TrueClone™ Collection and integrated its large number of otherwise inaccessible transcripts to enhance the coverage and usefulness of our infrastructure for high throughput biology and drug target discovery. PR-Xantos 8/12/04

CompuCyte Corporation and the National University of Singapore announced a collaborative program to study the cell-death-inducing activity of novel small compounds for their application in treating cancer and other disease conditions.  Under the agreement, NUS will provide CompuCyte with compounds, and CompuCyte will develop assays and perform high-content cell-based analysis of their effect on cells, using the company’s iCyte™ and iCys™ Imaging Cytometers.  PR-CompC 8/5/04
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