ChemDiv

ChemDiv is a global chemistry-driven contract research organization focused on discovery services for life science partners, merging industrial and academic efforts to deliver novel lead molecules and drug candidates. For two decades, ChemDiv has accelerated development of a new generation of medicines through our comprehensive Discovery outSource(TM) service, including Chemistry on Demand(TM), in-vitro and in-vivo capabilities, and IND preparation. Our global research network offers you cost-effective, fast track solutions tailored to your development needs.

ChemDiv now is developing a proprietary pipeline of exploratory-to-discovery and discovery-to-drug-candidate stage compounds in oncology, CNS, metabolic and infectious disease.

LEAD OPTIMIZATION TO CLINICAL CANDIDATE

ChemDiv is experienced in all processes along the drug discovery pathway. ChemDiv’s strengths and services include: Project and research strategy development, assessment of project tractability, early IP landscape analysis, assay development and design, screening, library design and synthesis, synthesis of singletons, structure activity relationships (SAR), DMPK analysis (Mouse, Rat, Dog, Monkey) and optimization, synthetic tractability and in-vivo assessment.

TRACK RECORD

ChemDiv has a track record of success with medicinal chemistry projects. Chemdiv has developed both selective and dual kinase inhibitors, vasculature-targeting agents, “non-toxic” anti-mitotics, dual and specific pGPCR antagonists, ion channel and developmental pathway modulators for leading biotechnology and pharmaceutical companies.

SCREENING LIBRARIES

ChemDiv is offers world's largest commercial compound library of 1.2 million drug-like compounds resulting from its extensive expertise in medicinal and synthetic chemistry.

FEATURES OF THE SCREENING LIBRARIES:

- More than 12,000 chemical templates representing over 1.2 million compounds
- 200,000 new compounds based on 1,500 new templates
- developed annually
- Pre-filtration using Rule-of-Five analysis and MedChem filters
- Comprehensive QC of all compounds
- QC by NMR, HPLC/MS or LC MS and other options
- Compound replenishing and back-up guarantee

The Focused Diversity approach and computational algorithms have been developed to assist in the analysis of chemical space, and characterization of target/ligand interactions:

- Fragment and property based diversity, completeness and lead likeness
- Strategic surveillance and novelty assessment
- Feasibility, parallel synthesis and validation
- Unique intermediate and protocol development
- QSAR and non-linear modelling
- High throughput QC
- Data mining and IT platform integration

TARGETED LIBRARIES

Features of the Targeted Collection:

- Size of library provided dependent on HTS capability
- Quarterly updated with proprietary compounds
- Target biased selections

-kinase, GPCR, phosphatase, ion channel, protease, nuclear receptor

- Antibacterial, Antiviral Selections
- Novel target based selections

-Hsp90, CB2, NaPi2b cotrasporter

- Recognition motifs and peptidomimetics

-Arg, Pro, Glu, Asp; beta-, gamma-turns; dipeptide- and tripeptide mimics, including RGD, AVPI and PDZ motifs, beta sheet, SH2 mimics

- Lead-like selection (Rule-of-Three) subsets biased for X-ray and NMR studies
- Natural products and respective synthetic libraries
- Focused Diversity Library annotated against orthogonal classes of targets
- Pathway and Cellular Process targeting compounds including annotated sets
- Antimitotics (vasculature-targeting agents (VTA), non-toxic MT modulators, kinesin, MAP binders)
-Hh-, Wnt- , HIF1-, pathway biased libraries

COMPOUND MANAGEMENT AND GLOBAL LOGISTICS
ChemDiv provides solutions for both compound acquisition and logistics support, including:

- Ordering of compounds from multiple suppliers (including thousands of sources in our global research network)
- High throughput QC, analytical and purification
- IT platform integration, data base procurement, mining and
- selection
- Library formatting, liquid and neat sample handling; dry / inert atmosphere
- Storage of chemical inventory; both automated and manual.
- Inventory and order tracking online, global in time distribution.

PRECLINICAL PROFILING SERVICES
- ChemDiv is your partner of choice for preclinical profiling backed up by our expertise in screening, biological evaluation, and pre-clinical optimization of small molecules against numerous internally developed and partner targets. ChemDiv can shorten your route from lead generation to clinical research by providing a full scope of preclinical testing to ensure the safety of your drug candidate and provide the data required for IND filing. 1-24 week toxicity studies are performed in small and large animal species with variety of dosing regimens.
- In vivo Pharmacokinetic Studies
- In vivo Toxicology Studies
- Single Dose Toxicity Studies
- Maximum Tolerated Dose Toxicity Studies
- Acute Toxicity Studies
- Sub-chronic and Chronic Toxicity studies
- CNS models
- Xenografts

Contact information:

Country:	United States
State:	California
City:	San Diego
Postal address:	6605 Nancy Ridge Drive
Postal code:	92121
Telephone number:	1-877-CHEMDIV or +1 858-794-4860
Fax:	858-794-4931
Web page:	http://www.chemdiv.com/
Email:	Contact us now