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• StemCyte and UC Davis Tethered in Umbilical Cord Blood Banking
  StemCyte entered an agreement with the UC Davis Umbilical Cord Blood Collection (UCB) Program to advance the collection, processing, and registration of high quality and diverse cord blood cells from California mothers for public banking. According to the company, the agreement is the first of its kind under California’s statewide program. Legislation signed into law [...]
  
  
• Horizon Applies Gene Editing to Huntington’s Disease
  Horizon Discovery inked a gene-editing research collaboration with the Institute of Neurology, University College London. The partnership will focus on the creation of human isogenic disease model cell lines with insertion of Huntington’s disease-causing triplet repeats. The company will provide UCL with access to GENESIS, its rAAV-mediated human gene-editing platform. This collaboration is a novel [...]
  
  
• New Pig Models for Cancer Studies
  A naturally occurring line of immunodeficient pigs can support the growth of human tumors injected under their skin, offering a promising new large-animal model for studying human cancers and testing new drugs and treatment strategies. The ability of human melanoma cells and pancreatic carcinoma cells to grow in these pig models is described in an [...]
  
  
• OGT Awarded $3.6M for Next-Generation Sequencing
  Oxford Gene Technology (OGT) next-generation sequencing service team has been awarded two EU-funded clinical research grants worth €3 million (approximately $3.6 million). OGT will be providing genomic analysis and commercialization services for two international studies, EUCLIDS and PATHSEEK. EUCLIDS (EU Life-threatening Infectious Disease Study), is a five-year, large-scale study to identify genomic variants that determine [...]
  
  
• Harrington Project Establishes BioMotiv Commercialization Arm
  A translational medicine investment company, BioMotiv, has been established as part of the $250 million Harrington Project for Discovery and Development initiative announced by University Hospitals in February. BioMotiv aims to raise initial capital of $100 million as it builds a portfolio of technologies in-licensed from academic medical centers associated with The Harrington Project and [...]
  
  
• Drug Safety Executive Council™ to Participate in 8th North American Drug Discovery Workshop: Discovery to IND: De-Risking Drug Discovery Programs Early
  Dr. Ernie Bush, Vice President of Collaborative Projects for DSEC, speaks on industry trends in predictive toxicology The Drug Safety Executive Council™ (DSEC™) is pleased to announce that Dr. Ernie Bush, Director of Collaborative Projects, is a featured speaker at the 8th North American Drug Discovery Workshop, co-sponsored by Cyprotex. Dr. Bush’s presentation is entitled [...]
  
  
• Sanford-Burnham robots speed up path to discovery
  The work force at Lake Nona’s Sanford- Burnham Institute includes 90 scientific staffers, 60 administrators and support personnel — and a team of three robots. The robots are part of a $15 million investment from the National Institutes of Health and occupy a large, glass-enclosed room on the bottom floor of Burnham’s Lake Nona campus. [...]
  
  
• Formulation strategies for improving drug solubility using solid dispersions
  Abstract: The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid dispersions have been employed to enhance the dissolution rates of poorly water – soluble drugs. This article reports various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration [...]
  
  
• The difficulties of Cushing’s syndrome
  Diagnosing and treating Cushing’s syndrome is sometimes just as difficult as it was 70 years ago. For as long as it has been described, Cushing’s syndrome has presented physicians with a problem. Harvey Cushing first described it in 1932, and the diagnosis, differential diagnosis and treatment of Cushing’s have remained a major challenge for endocrinologists [...]
  
  
• ERA-NET PathoGenoMics recognises outstanding PhD theses
  Increasingly, disease-causing microorganisms are being analysed on a genetic level in the hope of identifying critical factors that might be therapeutically applicable. European research in this area is being promoted under the roof of the ERA-NET PathoGenoMics network. During the 3rd European Conference on Procaryotic Genomics, held from 7 to 10 October in Göttingen, Germany, [...]